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300260 Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem

300260
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Key Spec Table

Empirical FormulaCAS #
C₁₂H₈ICl4673-26-1

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300260-10MGCN
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      Description
      OverviewA cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Also inhibits iNOS in macrophages (IC50 = 50 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADPH-ubiquinone oxido-reductase.
      Catalogue Number300260
      Brand Family Calbiochem®
      SynonymsDPI
      References
      ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
      Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
      Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
      Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
      Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
      Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
      Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.
      Product Information
      CAS number4673-26-1
      ATP CompetitiveN
      FormOff-white crystalline solid
      Hill FormulaC₁₂H₈ICl
      Chemical formulaC₁₂H₈ICl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargeteNOS
      Primary Target IC<sub>50</sub>180 nM against endothelial nitric oxide synthase (eNOS)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 42/43-63

      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Diphenyleneiodonium Chloride - CAS 4673-26-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      300260

      References

      Reference overview
      Wang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
      Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
      Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
      Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
      Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
      Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
      Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      SynonymsDPI
      DescriptionA cell-permeable, irreversible endothelial nitric oxide synthase inhibitor. Inhibits iNOS in macrophages (IC50 = 5 nM). Shown to inhibit acetylcholine-induced relaxation of preconstricted rat thoracic aortic rings (IC50 = 180 nM). Blocks K+ and Ca2+ currents in arterial smooth muscle cells. Inhibitor of mitochondrial NADH-ubiquinone oxidoreductase. Inhibits other NADH utilizing flavoproteins, such as NADPH oxidase in human neutrophils and macrophages. Causes pressor and tachycardiac effects via indirect activation of the sympathetic nervous system.
      FormOff-white crystalline solid
      CAS number4673-26-1
      Chemical formulaC₁₂H₈ICl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml). Slight warming is required for complete solubility.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesWang, Y.X., et al. 1995. Br. J. Pharmacol. 114, 194.
      Majander, A., et al. 1994. J. Biol. Chem. 269, 21037.
      Weir, E.K., et al. 1994. J. Appl. Physiol. 76, 2611.
      Wang, Y.X., et al. 1993. Br. J. Pharmacol. 110, 1232.
      Wang, Y.X., and Pang, C.C. 1993. Br. J. Pharmacol. 109, 1186.
      Stuehr, D.J., et al. 1991. FASEB J. 5, 98.
      Handcock, J.T., and Jones, O.T.G. 1987. Biochem. J. 242, 103.