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05-23-3800 Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

05-23-3800
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₀₉H₁₅₉N₂₅O₃₂S₅117399-94-7

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05-23-3800-0.1MGCN
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      Plastic ampoule .1 mg
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      05-23-3800-0.5MGCN
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          Plastic ampoule .5 mg
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          Description
          OverviewA 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
          Catalogue Number05-23-3800
          Brand Family Calbiochem®
          SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
          References
          ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
          Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
          Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
          Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
          Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
          Yanagisawa, M., et al. 1988. Nature 332, 411.
          Product Information
          CAS number117399-94-7
          ATP CompetitiveN
          FormWhite to off-white solid
          FormulationSupplied as an acetate salt.
          Hill FormulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
          Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
          ReversibleN
          Sold on the basis of peptide contentY
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetPotent vasoconstrictive action
          Purity≥96% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem Certificates of Analysis

          TitleLot Number
          05-23-3800

          References

          Reference overview
          Cesari, M., et al. 1996. Am. Heart J. 132, 1236.
          Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
          Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
          Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
          Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
          Yanagisawa, M., et al. 1988. Nature 332, 411.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-May-2008 JSW
          SynonymsET-1, CSCSSLMDKECVYFCHLDIIW
          DescriptionA 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca2+ channels. Reported to activate phospholipase C in fibroblasts expressing ETA receptors.
          FormWhite to off-white solid
          FormulationSupplied as an acetate salt.
          CAS number117399-94-7
          Chemical formulaC₁₀₉H₁₅₉N₂₅O₃₂S₅
          Peptide SequenceH-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
          Purity≥96% by HPLC
          Solubility5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Toxicity Standard Handling
          ReferencesCesari, M., et al. 1996. Am. Heart J. 132, 1236.
          Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169.
          Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524.
          Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294.
          Itoh, Y., et al. 1988. FEBS Lett. 231, 440.
          Yanagisawa, M., et al. 1988. Nature 332, 411.