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344580 FtsZ Polymer Stabilizer, PC190723 - Calbiochem

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affectE. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer

Primary Target: FtsZ
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344580
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₈ClF₂N₃O₂S

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      		 Glass bottle 5 mg
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      Description
      OverviewA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 μg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
      Catalogue Number344580
      Brand Family Calbiochem®
      Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
      References
      ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
      Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
      Haydon, D. J., et al. 2008. Science, 321, 1673.
      Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
      Product Information
      FormTan powder
      Hill FormulaC₁₄H₈ClF₂N₃O₂S
      Chemical formulaC₁₄H₈ClF₂N₃O₂S
      HS Code2934 99 99
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFtsZ
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      344580-5MGCN 04055977214789

      Documentation

      FtsZ Polymer Stabilizer, PC190723 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      FtsZ Polymer Stabilizer, PC190723 - Calbiochem Certificates of Analysis

      TitleLot Number
      344580

      References

      Reference overview
      Elsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
      Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
      Haydon, D. J., et al. 2008. Science, 321, 1673.
      Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2013 JSW
      Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
      DescriptionA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 μg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubuin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
      FormTan powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₈ClF₂N₃O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
      Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
      Haydon, D. J., et al. 2008. Science, 321, 1673.
      Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.