361540 GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem

361540
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₀H₁₀N₂SO₂327036-89-5

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361540-5MGCN
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      Description
      OverviewA thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
      Catalogue Number361540
      Brand Family Calbiochem®
      SynonymsTDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
      References
      ReferencesGuzman, M.L., et al. 2007. Blood 110, 4436.
      Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
      Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.
      Product Information
      CAS number327036-89-5
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₁₀H₁₀N₂SO₂
      Chemical formulaC₁₀H₁₀N₂SO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>2 µM, 673 nM, 1.4-5.5 µM, against GSK-3β, Flt-3, and PKC activities, respectively
      Purity≥ 95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      361540

      References

      Reference overview
      Guzman, M.L., et al. 2007. Blood 110, 4436.
      Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
      Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.

      Brochure

      Title
      Alzheimer's Disease Brochure & Technical Guide
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      SynonymsTDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
      DescriptionA cell-permeable, thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP-competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk1/cyclin B, CK-II, PKA, or PKC (IC50 >100 µM). Shown to inhibit collagen- and thrombin-induced platelet aggregation.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number327036-89-5
      Chemical formulaC₁₀H₁₀N₂SO₂
      Structure formulaStructure formula
      Purity≥ 95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGuzman, M.L., et al. 2007. Blood 110, 4436.
      Barry, F.A., et al. 2003. FEBS Lett. 553, 173.
      Martinez, A., et al. 2002. J. Med. Chem. 45, 1292.