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CC1025 Human Integrin αVβ5, Triton X-100 Formulation

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control UniProt Number: P06756 Entrez Gene Number: NM_002210.2
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CC1025
50 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberCC1025
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionHuman Integrin αVβ5, Triton X-100 Formulation
      OverviewIntegrin alphaV beta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaV beta5 integrin. Two bands are identified with silver stain, corresponding to alphaV (145kDa) and beta5 (90kDa) subunits under nonreducing conditions. Product was tested and found negative for HIV, HBsAg, syphilis, and hepatitis. Integrin alphaV beta5 interacts with vitronectin in ELISA.
      References
      Product Information
      PresentationPurified protein in 20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 2 mM MgCl, 0.2% Triton X-100, with no preservatives.
      Quality LevelMQ100
      Applications
      Key Applications
      • Positive Control
      Application NotesElectrophoresis, Immunoblotting, and Ligand Binding studies.
      Biological Information
      Purity>95% by SDS-PAGE (silver stain) Two main protein bands corresponding to aV (145 kD) and β5 (90 kD) subunits are seen in silver stained

      gel under non-reduced conditions.
      Entrez Gene Number
      Entrez Gene SummaryITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
      Gene Symbol
      • ITGAV
      • DKFZp686A08142
      • MSK8
      • CD51
      • VNRA
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
      SIZE: 1048 amino acids; 116038 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots. Avoid repeated freeze/ thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      CC1025 04053252405457

      Documentation

      Human Integrin αVβ5, Triton X-100 Formulation SDS

      Title

      Safety Data Sheet (SDS) 

      Human Integrin αVβ5, Triton X-100 Formulation Certificates of Analysis

      TitleLot Number
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 2101952 2101952
      HUMAN INTEGRIN alphaV beta5 - 3192042 3192042
      HUMAN INTEGRIN alphaV beta5 - 3715132 3715132
      HUMAN INTEGRIN alphaV beta5 -2607290 2607290
      HUMAN INTEGRIN alphaV beta5 -2846398 2846398
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION 2984207
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION 3057116
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 2013399 2013399
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION - 3978937 3978937

      Data Sheet

      Title
      HUMAN INTEGRIN alphaV beta5 PURIFIED PROTEIN TRITON FORMULATION