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390602 Hydroxyfasudil - CAS 155558-32-0 - Calbiochem

A cell-permeable, hydroxylated metabolite of HA 1077 that displays anti-anginal properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100, ROCK Inhibitor XIV

Primary Target: Rho-kinase
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390602
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
155558-32-0C₁₄H₁₇N₃O₃S • HCl

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      Description
      OverviewA cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
      Catalogue Number390602
      Brand Family Calbiochem®
      Synonyms1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100, ROCK Inhibitor XIV
      References
      ReferencesIto, K., et al. 2003. J. Physiol. 546, 823.
      Takemoto, M., et al. 2002. Circulation 106, 57.
      Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.
      Product Information
      CAS number155558-32-0
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (2 mg/582 µl) solution in H₂O.
      Hill FormulaC₁₄H₁₇N₃O₃S • HCl
      Chemical formulaC₁₄H₁₇N₃O₃S • HCl
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRho-kinase
      Primary Target IC<sub>50</sub>0.9 and 1.8 µM against Rho-kinase using a peptide and MLC as substrate, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      390602-2MGCN 04055977189995

      Documentation

      Hydroxyfasudil - CAS 155558-32-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Hydroxyfasudil - CAS 155558-32-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      390602

      References

      Reference overview
      Ito, K., et al. 2003. J. Physiol. 546, 823.
      Takemoto, M., et al. 2002. Circulation 106, 57.
      Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-March-2008 JSW
      Synonyms1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100, ROCK Inhibitor XIV
      DescriptionA cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
      FormLiquid
      FormulationA 10 mM (2 mg/582 µl) solution in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number155558-32-0
      Chemical formulaC₁₄H₁₇N₃O₃S • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful
      ReferencesIto, K., et al. 2003. J. Physiol. 546, 823.
      Takemoto, M., et al. 2002. Circulation 106, 57.
      Shimokawa, H., et al. 1999. Cardiovasc. Res. 43, 1029.