500583 InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem

500583
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₂₄O₄20350-15-6

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      Glass bottle 2 mg
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      Description
      Catalogue Number500583
      Brand Family Calbiochem®
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
      References
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Product Information
      CAS number20350-15-6
      FormLiquid
      FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
      Hill FormulaC₁₆H₂₄O₄
      Chemical formulaC₁₆H₂₄O₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetADP-ribosylation factor (ARF)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Yamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-July-2014 JSW
      Synonyms1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one, (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one, CID 5287620, Cyanaein
      DescriptionSpecifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange.
      FormLiquid
      FormulationA 25 mM (2 mg/285 µL) solution of (+)-Brefeldin A (Cat. No. 203729) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number20350-15-6
      Chemical formulaC₁₆H₂₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. Use only fresh DMSO for further dilutions prior to use.
      Toxicity Irritant
      ReferencesYamagi, R., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 2567.
      Moriango, N., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 12856.
      Mendez, A.J. 1995. J. Biol. Chem. 270, 5891.
      Ridgway, N.D., et al. 1995. J. Biol. Chem.270, 8023.
      Tsai, S.C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3063.
      Ktistakis, N.Y., et al. 1992. Nature 356, 344.