509612 InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem

509612
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₃₇N₅O₅187034-31-7

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      Glass bottle 1 mg
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      Description
      Catalogue Number509612
      Brand Family Calbiochem®
      References
      ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
      Product Information
      CAS number187034-31-7
      FormLiquid
      FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
      Hill FormulaC₁₉H₃₇N₅O₅
      Chemical formulaC₁₉H₃₇N₅O₅
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2014 JSW
      DescriptionA hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
      FormLiquid
      FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number187034-31-7
      Chemical formulaC₁₉H₃₇N₅O₅
      Purity≥97% by HPLC
      Storage ≤ -70°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
      Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Parvathy, S., et al. 1997. Biochem. J. 327, 37.
      Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.