688002 InSolution™ Y-27632 in DMSO - Calbiochem

688002
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄H₂₁N₃O•2HCl•H₂O

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688002-1MGCN
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      Glass bottle 1 mg
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      Description
      OverviewA highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
      Catalogue Number688002
      Brand Family Calbiochem®
      Synonyms(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
      References
      ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science 285, 895.
      Uehata, M., et al. 1997. Nature 389, 990.
      Product Information
      FormLiquid
      FormulationA 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
      Hill FormulaC₁₄H₂₁N₃O•2HCl•H₂O
      Chemical formulaC₁₄H₂₁N₃O•2HCl•H₂O
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Y-27632 in DMSO - Calbiochem Certificates of Analysis

      TitleLot Number
      688002

      References

      Reference overview
      Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science 285, 895.
      Uehata, M., et al. 1997. Nature 389, 990.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-January-2012 RFH
      Synonyms(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
      DescriptionA highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
      FormLiquid
      FormulationA 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
      Chemical formulaC₁₄H₂₁N₃O•2HCl•H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Irritant
      ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
      Chitaley, K., et al. 2001. Nat. Med. 7, 119.
      Davies, S.P., et al. 2000. Biochem. J. 351, 95.
      Narumiya, S., et al. 2000. Methods Enzymol. 325, 273.
      Hirose, M., et al. 1998. J. Cell Biol. 141, 1625.
      Maekawa, M., et al. 1999. Science 285, 895.
      Uehata, M., et al. 1997. Nature 389, 990.