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420119 JNK Inhibitor II - CAS 129-56-6 - Calbiochem

420119
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
129-56-6C₁₄H₈N₂O

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420119-25MGCN
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      Plastic ampoule 25 mg
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      420119-5MGCN
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          Description
          OverviewA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.
          Catalogue Number420119
          Brand Family Calbiochem®
          SynonymsSAPK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125
          References
          ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Product Information
          CAS number129-56-6
          ATP CompetitiveY
          FormYellowish orange solid
          Hill FormulaC₁₄H₈N₂O
          Chemical formulaC₁₄H₈N₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ200
          Applications
          ApplicationJNK Inhibitor II, CAS 129-56-6, is a cell-permeable, potent, selective, ATP-competitive, and reversible inhibitor of c-Jun N-terminal kinase (IC50 = 40 nM for JNK-1 & 2 & 90 nM for JNK-3).
          Biological Information
          Primary TargetJNK 1, JNK 2, JNK 3
          Primary Target IC<sub>50</sub>40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSCB4585000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          JNK Inhibitor II - CAS 129-56-6 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          JNK Inhibitor II - CAS 129-56-6 - Calbiochem Certificates of Analysis

          TitleLot Number
          420119

          References

          Reference overview
          Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.

          Citations

          Title
        • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
        • Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling. (2005) Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. Journal of Pharmacology and Experimental Therapeutics in press,.
        • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-June-2009 RFH
          SynonymsSAPK Inhibitor II, Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-pyrazoloanthrone, SP600125
          DescriptionA potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks the expression of IL-2, IFN-γ, TNF-α, and COX-2 in cells. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription.
          FormYellowish orange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number129-56-6
          RTECSCB4585000
          Chemical formulaC₁₄H₈N₂O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (15 mg/ml). For every 10 µM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
          Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
          Han, Z., et al. 2001. J. Clin. Invest. 108, 73.
          Citation
        • Alexandra Thiel, et al. (2006) Expression of Cyclooxygenase-2 Is Regulated by Glycogen Synthase Kinase-3beta in Gastric Cancer Cells. Journal of Biological Chemistry 281, 4564-4569.
        • Yuseok Moon, Wayne C. Glasgow and Thomas E. Eling. (2005) Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 (mPGES-1) by altering early growth response gene EGR-1 and other signaling pathways. Journal of Pharmacology and Experimental Therapeutics in press,.
        • Naoto Inukai, et al. (2004) A novel hydrogen peroxide-induced phosphorylation and ubiquitination pathway leading to RNA polymerase II proteolysis. Journal of Biological Chemistry 279, 8190-8195.