420336 KB-R7943 - CAS 182004-65-5 - Calbiochem

420336
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₇N₃O₃S • MeSO₃H182004-65-5

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420336-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM).
      Catalogue Number420336
      Brand Family Calbiochem®
      Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
      References
      ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
      Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
      Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
      Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
      Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
      Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
      Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
      Product Information
      CAS number182004-65-5
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₆H₁₇N₃O₃S • MeSO₃H
      Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+/Ca2+ exchangers
      Primary Target IC<sub>50</sub>4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KB-R7943 - CAS 182004-65-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      420336

      References

      Reference overview
      Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
      Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
      Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
      Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
      Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
      Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
      Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-July-2008 RFH
      Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
      DescriptionA cell-permeable inhibitor of the influx/reverse mode of the Na+/Ca2+ exchanger (NCX) (IC50 = 4.3 µM for NCX1, 4.7 µM for NCX2, and 1.4 µM for NCX3). Directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 <10 µM).
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number182004-65-5
      Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (40 mg/ml) or H₂O (4 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
      Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
      Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
      Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
      Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
      Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
      Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.