420320 KT5720 - CAS 108068-98-0 - Calbiochem

420320
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Key Spec Table

Empirical FormulaCAS #
C₃₂H₃₁N₃O₅108068-98-0

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420320-100UGCN
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      Glass bottle 100 μg
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      Description
      OverviewA potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.
      Catalogue Number420320
      Brand Family Calbiochem®
      SynonymsPKA Inhibitor VII
      References
      ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
      Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
      Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Product Information
      CAS number108068-98-0
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₃₂H₃₁N₃O₅
      Chemical formulaC₃₂H₃₁N₃O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationKT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.
      Biological Information
      Primary TargetPKA
      Primary Target K<sub>i</sub>56 nM for protein kinase A
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KT5720 - CAS 108068-98-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      KT5720 - CAS 108068-98-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      420320

      References

      Reference overview
      Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
      Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
      Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

      Citations

      Title
    • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-January-2010 RFH
      SynonymsPKA Inhibitor VII
      DescriptionPrepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.
      FormWhite solid
      CAS number108068-98-0
      Chemical formulaC₃₂H₃₁N₃O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
      Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
      Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
      Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
      Citation
    • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.