506271 Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem

506271
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₂H₂₂FN₃O₃·C₄H₆O₆83846-83-7

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      Glass bottle 50 mg
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      Description
      OverviewA selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
      Catalogue Number506271
      Brand Family Calbiochem®
      Synonyms5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
      References
      ReferencesRos, R. et al. 2013. PNAS. 110, 348.
      Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
      Leysen, J. E. et al. 1981. Life Sci. 28, 1015.
      Product Information
      CAS number83846-83-7
      FormWhite solid
      Hill FormulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
      Chemical formulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT2A
      Primary Target K<sub>i</sub>1.49 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 46

      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Ros, R. et al. 2013. PNAS. 110, 348.
      Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
      Leysen, J. E. et al. 1981. Life Sci. 28, 1015.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      Synonyms5-HT2A Serotonin Receptor Antagonist, Ketanserin, R 41 468
      DescriptionA selective 5-HT2A serotonin receptor antagonist with weak adrenergic receptor blocking properties. Strong affinity for 5-HT2AR (Ki = 1.49 nM) relative to other family members like 5-HT2BR (Ki = 740 nM) and 5-HT2CR (Ki = 59 nM). Often used in conjunction with SB 206553 to distinguish 5-HT2AR and 5-HT2CR activity.
      FormWhite solid
      CAS number83846-83-7
      Chemical formulaC₂₂H₂₂FN₃O₃·C₄H₆O₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesRos, R. et al. 2013. PNAS. 110, 348.
      Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
      Aloyo, V. J. and Harvey, J. A. 2000. Eur. J. Pharmacol. 406, 163.
      Leysen, J. E. et al. 1981. Life Sci. 28, 1015.