427218 Lactate Dehydrogenase A Inhibitor, FX11 - Calbiochem

427218
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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
      Catalogue Number427218
      Brand Family Calbiochem®
      SynonymsLDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I
      References
      ReferencesLe, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
      Deck, L. M., et al. 1998. J Med Chem. 41, 3879.
      Product Information
      CAS number213971-34-7
      FormWhite solid
      Hill FormulaC₂₂H₂₂O₄
      Chemical formulaC₂₂H₂₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationLactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
      Biological Information
      Primary TargetLDHA
      Primary Target K<sub>i</sub>8 µ
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Lactate Dehydrogenase A Inhibitor, FX11 - Calbiochem Certificates of Analysis

      TitleLot Number
      427218

      References

      Reference overview
      Le, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
      Deck, L. M., et al. 1998. J Med Chem. 41, 3879.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-December-2013 JSW
      SynonymsLDH-A Inhibitor I, LDH-M Inhibitor I, LDHM Inhibitor I, LDHA Inhibitor I
      DescriptionA cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number213971-34-7
      Chemical formulaC₂₂H₂₂O₄
      Structure formulaStructure formula
      Purity≥96% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLe, A., et al. 2011. Proc Natl Acad Sci USA. 107, 2037.
      Deck, L. M., et al. 1998. J Med Chem. 41, 3879.