508162 Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem

508162
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₉H₃₃ClN₂O₂·HCl34552-83-5

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      Glass bottle 1 gm
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      Description
      OverviewA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
      Catalogue Number508162
      Brand Family Calbiochem®
      Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
      References
      ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
      Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
      DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
      Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
      Product Information
      CAS number34552-83-5
      FormWhite solid
      Hill FormulaC₂₉H₃₃ClN₂O₂·HCl
      Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetu opioid receptor
      Primary Target K<sub>i</sub>2 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 36/37/39-46

      Wear suitable protective clothing, gloves and eye/face protection.
      If swallowed, seek medical advice immediately and show this container or label.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Loperamide Hydrochloride - CAS 34552-83-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      508162

      References

      Reference overview
      Cheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
      Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
      DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
      Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonymsµ-Opioid Receptor Agonist, Loperamide Hydrochloride, Imodium
      DescriptionA very potent and highly selective peripheral resctricted µ-opioid receptor agonist (Ki = 2 nM). Often used as an antidiarrheal, antipruritic, and antihyperalgesic agent. In addition, shown to improve defective post-receptor insulin signaling in skeletal muscle cells and enhance insulin sensitivity in rats.
      FormWhite solid
      CAS number34552-83-5
      Chemical formulaC₂₉H₃₃ClN₂O₂·HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mM) or Ethanol (50 mM). Warming is required for complete solubilization in ethanol.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesCheng, K., et al. 2013. Pharmaco. Ther. 139, 334.
      Di Bosco, M., et al. 2008. Chem. Biol. Drug Des. 71, 328.
      DeHaven-Hudkins, D., et al. 1999. J. Pharmacol. Exp. Ther. 289, 494.
      Mackerer, C., et al. 1976. J. Pharmacol. Exp. Ther. 199, 131.