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444180 MAP Kinase Inhibitor Set I - Calbiochem

444180
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444180-1SETCN
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      Description
      OverviewContains 5 mg of the MEK inhibitor PD 98059 (Cat. No. 513000), 1 mg each of the MAP kinase inhibitors SB 202190 (Cat. No. 559388) and SB 203580 (Cat. No. 559389), and 1 mg of Proteasome Inhibitor I (Cat. No. 539160), which serves as a negative control. Supplied with a data sheet.
      Catalogue Number444180
      Brand Family Calbiochem®
      References
      Product Information
      FormSolid
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp38 kinase
      Primary Target IC<sub>50</sub>350 nM, 600 nM
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and store at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MAP Kinase Inhibitor Set I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MAP Kinase Inhibitor Set I - Calbiochem Certificates of Analysis

      TitleLot Number
      444180

      Brochure

      Title
      Protein Kinase Assay and Detection Kits Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2020 JSW
      DescriptionMAP (mitogen-activated protein) kinases are ubiquitous serine/threonine kinases that are activated by a wide variety of extracellular signals. The MAP kinase cascade plays a crucial role in signal transduction from the membrane to the nucleus and appears to be highly conserved throughout evolution. In mammalian cells, this cascade is activated by both tyrosine kinase receptors and G-protein coupled receptors. MAP kinase activation, an essential step in triggering cell cycle progression, leads to changes in properties of cytoplasmic, membrane-associated and nuclear proteins. A unique feature of MAP kinases is that their full activation requires phosphorylation of both a threonine residue and a tyrosine residue which are separated by a single amino acid. This phosphorylation is brought about by the action of MAP kinase kinase (MEK), a dual specificity kinase. Once activated, MAP kinase relays signals downstream by phosphorylating various other protein kinases and regulatory proteins. Following activation, MAP kinases translocate from the cytosol into the nucleus and phosphorylate a number of transcription factors leading to changes in gene expression. Supplied with a data sheet.
      FormSolid
      SolubilityThese inhibitors are soluble in DMSO.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and store at -20°C.
      Toxicity Standard Handling