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443300 MCI-186 - CAS 89-25-8 - Calbiochem

A free radical scavenger and antioxidant that reduces post-ischemic brain injury.

MCI-186 - CAS 89-25-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone

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443300
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
89-25-8C₁₀H₁₀N₂O

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443300-500MGCN
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      Description
      OverviewA free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
      Catalogue Number443300
      Brand Family Calbiochem®
      Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
      References
      ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
      Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
      Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
      Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
      Nishi, H., et al. 1989. Stroke 20, 1236.
      Product Information
      CAS number89-25-8
      ATP CompetitiveN
      FormCream-colored solid
      Hill FormulaC₁₀H₁₀N₂O
      Chemical formulaC₁₀H₁₀N₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA free radical scavenger and antioxidant
      Primary Target IC<sub>50</sub>15 µM inhibiting iron-dependent peroxidation in rat brain homogenates
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUQ9625000
      Safety Information
      R PhraseR: 22-36/37/38-43

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      443300-500MGCN 04055977205350

      Documentation

      MCI-186 - CAS 89-25-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MCI-186 - CAS 89-25-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      443300

      References

      Reference overview
      Katare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
      Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
      Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
      Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
      Nishi, H., et al. 1989. Stroke 20, 1236.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 JSW
      Synonyms3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone
      DescriptionA free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 µM). Inhibits mitochondrial permeability transition pore.
      FormCream-colored solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number89-25-8
      RTECSUQ9625000
      Chemical formulaC₁₀H₁₀N₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 6713
      ReferencesKatare, R. G., et al. 2003. Am. J. Physiol. 285, H2171.
      Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
      Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
      Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
      Nishi, H., et al. 1989. Stroke 20, 1236.