475863 MK2a Inhibitor - CAS 41179-33-3 - Calbiochem

475863
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₂H₂₀FNO₂41179-33-3

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      Plastic ampoule 5 mg
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      Description
      OverviewA reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
      Catalogue Number475863
      Brand Family Calbiochem®
      SynonymsMitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
      References
      ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.
      Product Information
      CAS number41179-33-3
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₂H₂₀FNO₂
      Chemical formulaC₂₂H₂₀FNO₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMk2α
      Primary Target K<sub>i</sub>Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MK2a Inhibitor - CAS 41179-33-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      475863

      References

      Reference overview
      Davidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      SynonymsMitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1, MAPKAPK2a Inhibitor
      DescriptionA non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number41179-33-3
      Chemical formulaC₂₂H₂₀FNO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.