444252 MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem

444252
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₅H₂₅N₃O₆S204140-01-2

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444252-1MGCN
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      Plastic ampoule 1 mg
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      Description
      OverviewA piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
      Catalogue Number444252
      Brand Family Calbiochem®
      SynonymsN-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
      References
      ReferencesCheng, M., et al. 2000. J. Med. Chem. 43, 369.
      Product Information
      CAS number204140-01-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₅H₂₅N₃O₆S
      Chemical formulaC₂₅H₂₅N₃O₆S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-9
      Primary Target IC<sub>50</sub>900 pM against both MMP-9 and MMP-13
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      444252

      References

      Reference overview
      Cheng, M., et al. 2000. J. Med. Chem. 43, 369.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      SynonymsN-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
      DescriptionA cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number204140-01-2
      Chemical formulaC₂₅H₂₅N₃O₆S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (1 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCheng, M., et al. 2000. J. Med. Chem. 43, 369.