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475951 MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: S-(3,4-Dichlorobenzyl)isothiourea, HCl

Primary Target: MreB
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475951
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22816-60-0C₈H₈Cl₂N₂S • HCl

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475951-25MGCN
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      		 Plastic ampoule 25 mg
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      Description
      OverviewA cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
      Catalogue Number475951
      Brand Family Calbiochem®
      SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
      References
      ReferencesGitai, Z., et al. 2005. Cell 120, 329.
      Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
      Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
      Product Information
      CAS number22816-60-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₈Cl₂N₂S • HCl
      Chemical formulaC₈H₈Cl₂N₂S • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMreB
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475951-25MGCN 07790788050580

      Documentation

      MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      475951

      References

      Reference overview
      Gitai, Z., et al. 2005. Cell 120, 329.
      Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
      Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
      DescriptionA cell-permeable isothiourea compound that specifically, rapidly, and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with the nucleotide binding pocket of MreB and is useful for the temporal analysis of MreB function.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22816-60-0
      Chemical formulaC₈H₈Cl₂N₂S • HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or H₂O (2 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
      Toxicity Standard Handling
      ReferencesGitai, Z., et al. 2005. Cell 120, 329.
      Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
      Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.