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532759 NOX1 Inhibitor, NoxA1ds Set - Calbiochem

A cell-permeable peptide that acts as a highly potent,isoform specific inhibitor of NADPH oxidase 1 (IC₅₀ = 19 nM). Binds to NOX1 and disrupts its interaction with its activator subunit (NOXA1).

NOX1 Inhibitor, NoxA1ds Set - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NADPH Oxidase 1 Inhibitor, NoxA1ds, NADPH-oxidase inhibitor, NoxA1ds

Primary Target: NOX1
532759
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₀H₈₈N₁₄O₁₅

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      Description
      OverviewA cell permeable peptide derived from the activation domain of NOXA1, with Y199A substitution that acts as a highly potent and isoform specific inhibitor of NADPH oxidase 1 (NOX1; IC50 = 19 nM). Acts by binding to NOX1 and disrupts its interaction with its activator subunit (NOXA1). Shown to block NOX1-derived production of superoxide ( O2.- ) in a reconstituted NOX1 cell-free system, but does not affect NOX2, NOX4, NOX5 or xanthine oxidase derived superoxide and has no scavenging effects on either superoxide or hydrogen peroxide. Also suppresses superoxide production in NOX1 expressing HT-29 colon carcinoma cells (IC50 = 100 nM) and in hypoxia-induced human pulmonary artery endothelial cells (HPAEC), but does not affect O2.- production in peritoneal macropages derived from NOX1-null mice. A scrambled peptide is also included as a negative control.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532759
      Brand Family Calbiochem®
      SynonymsNADPH Oxidase 1 Inhibitor, NoxA1ds, NADPH-oxidase inhibitor, NoxA1ds
      References
      ReferencesRanayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.
      Product Information
      FormWhite solid
      Formulation1 set contains 5 mg NOX1 Inhibitor, NoxA1ds (Cat. No. 5.32760.0001) and 5 mg NOX1 Inhibitor, NoxA1ds Negative Control (Cat. No. 5.32761.0001).
      Hill FormulaC₅₀H₈₈N₁₄O₁₅
      Chemical formulaC₅₀H₈₈N₁₄O₁₅
      Hygroscopic Hygroscopic
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNOX1
      Primary Target IC<sub>50</sub>19 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceNOX1 Inhibitor, NoxA1ds: NH3-EPVDALGKAKV-CONH2
      NOX1 Inhibitor, NoxA1ds Negative Control: NH2-LVKGPDAEKVA-CONH2
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5.32759.0001 04055977281903

      Documentation

      NOX1 Inhibitor, NoxA1ds Set - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Ranayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.

      Brochure

      Title
      Neuroscience Solutions for productive research
      Pathways and Biomarkers of Oxidative Stress

      Technical Info

      Title
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      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-September-2020 JSW
      SynonymsNADPH Oxidase 1 Inhibitor, NoxA1ds, NADPH-oxidase inhibitor, NoxA1ds
      FormWhite solid
      Formulation1 set contains 5 mg NOX1 Inhibitor, NoxA1ds (Cat. No. 5.32760.0001) and 5 mg NOX1 Inhibitor, NoxA1ds Negative Control (Cat. No. 5.32761.0001).
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅₀H₈₈N₁₄O₁₅
      Peptide SequenceNOX1 Inhibitor, NoxA1ds: NH3-EPVDALGKAKV-CONH2
      NOX1 Inhibitor, NoxA1ds Negative Control: NH2-LVKGPDAEKVA-CONH2
      Purity≥98% by HPLC
      SolubilityH₂0 (50 mg/ml), DMSO (50 mg/ml), or Methanol (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesRanayhossaini, D.J., et al. 2013. J. Bio. Chem. 288, 36437.