513022 PD 150606 - CAS 426821-41-2 - Calbiochem

513022
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₉H₇IO₂S426821-41-2

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
513022-5MGCN
Retrieving availability...
Limited AvailabilityLimited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
      Catalogue Number513022
      Brand Family Calbiochem®
      Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
      References
      ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Product Information
      CAS number426821-41-2
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₉H₇IO₂S
      Chemical formulaC₉H₇IO₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCalpain-1
      Primary Target K<sub>i</sub>210 nM for calpain-1 and 370 nM for calpain-2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      PD 150606 - CAS 426821-41-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      513022

      References

      Reference overview
      Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

      Citations

      Title
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2011 RFH
      Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
      DescriptionA cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number426821-41-2
      Chemical formulaC₉H₇IO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
      Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
      Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
      Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
      Citation
    • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.