512732 Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

512732
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₂₀O₃20554-84-1

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512732-50MGCN
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      Plastic ampoule 50 mg
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      Description
      OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
      Catalogue Number512732
      Brand Family Calbiochem®
      References
      ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
      Product Information
      CAS number20554-84-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₂₀O₃
      Chemical formulaC₁₅H₂₀O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLY4220000
      Safety Information
      R PhraseR: 20/21/22-40-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      512732

      References

      Reference overview
      Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      DescriptionA sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
      FormWhite solid
      CAS number20554-84-1
      RTECSLY4220000
      Chemical formulaC₁₅H₂₀O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml) or ethanol (20 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.