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516485 Pepstatin A Methyl Ester - Calbiochem

516485
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₅H₆₅N₅O₉

Pricing & Availability

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516485-1MGCN
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      Description
      OverviewA cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 150 nM, Kii = 320 nM in solubilized human γ-secretase at 20°C; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.
      Catalogue Number516485
      Brand Family Calbiochem®
      SynonymsIsovaleryl-V V-Sta-A-Sta-OCH₃, PME
      References
      ReferencesTian, G., et al. 2002. J. Biol. Chem. 277, 31499.
      Zhang, L., et al. 2001. Biochemistry 40, 5049.
      Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₃₅H₆₅N₅O₉
      Chemical formulaC₃₅H₆₅N₅O₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetγ-secretase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Pepstatin A Methyl Ester - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Pepstatin A Methyl Ester - Calbiochem Certificates of Analysis

      TitleLot Number
      516485

      References

      Reference overview
      Tian, G., et al. 2002. J. Biol. Chem. 277, 31499.
      Zhang, L., et al. 2001. Biochemistry 40, 5049.
      Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      SynonymsIsovaleryl-V V-Sta-A-Sta-OCH₃, PME
      DescriptionA cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516482) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (Kis = 15 nM and Kii = 32 nM in solubilized human γ-secretase; Kis is the inhibition constant for inhibitor binding to the free enzyme and Kii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex).
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₅H₆₅N₅O₉
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesTian, G., et al. 2002. J. Biol. Chem. 277, 31499.
      Zhang, L., et al. 2001. Biochemistry 40, 5049.
      Murphy, M.P., et al. 1999. J. Biol. Chem. 274, 11914.