524390 Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

524390
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₈H₄₀O₈37558-16-0

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524390-1MGCN
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      Alu drum 1 mg
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      Description
      OverviewStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C. Stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity. Promotes the expression of inducible NOS in cultured hepatocytes. Commonly used in binding studies or in applications requiring high concentrations of phorbol compounds.
      Catalogue Number524390
      Brand Family Calbiochem®
      SynonymsPDBu, PKC Activator II
      References
      ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
      Lee, E.J., et al. 1994. Brain Res. 665, 127.
      Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
      Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
      Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.
      Product Information
      CAS number37558-16-0
      ATP CompetitiveN
      FormClear film or white crystalline solid
      Hill FormulaC₂₈H₄₀O₈
      Chemical formulaC₂₈H₄₀O₈
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNa+,K+- ATPase
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEK7767000
      Safety Information
      R PhraseR: 26/27/28-36/37/38-40-41

      Very toxic by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      Limited evidence of a carcinogenic effect.
      Risk of serious damage to eyes.
      S PhraseS: 26-36/37/39-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      524390

      References

      Reference overview
      Fisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
      Lee, E.J., et al. 1994. Brain Res. 665, 127.
      Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
      Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
      Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      SynonymsPDBu, PKC Activator II
      DescriptionStrong irritant for mouse skin, but only moderately active as a tumor promoter. Activates protein kinase C (PKC). Stimulates the phosphorylation of Na+-K+ ATPase, thereby inhibiting its activity. Promotes the expression of iNOS in cultured hepatocytes. PDBu can be diluted to 30 µM in aqueous solutions, so it is commonly used in binding studies or in applications requiring high concentrations. It is easier to remove PDBu than PMA from cells in culture.
      FormClear film or white crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number37558-16-0
      RTECSEK7767000
      Chemical formulaC₂₈H₄₀O₈
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (10 mg/ml). Further dilute with aqueous buffers just prior to use.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. With frequent use, the DMSO stock solutions may accumulate water. The presence of water in the stock solution will accelerate the decomposition of the product, resulting in significant loss of activity in 2-3 months.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      ReferencesFisone, G., et al. 1995. J. Biol. Chem. 270, 2427.
      Lee, E.J., et al. 1994. Brain Res. 665, 127.
      Critz, S.D., et al. 1993. J. Neurochem. 60, 1175.
      Iredale, P.A., et al. 1993. Biochem. Pharmacol. 45, 611.
      Critz, S.D., and Byrne J.H. 1992. J. Neurophys. 68, 1079.
      Hortelano, S., et al. 1992. J. Biol. Chem. 267, 24937.
      Ward C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol. 24, 937.