506026 REST Inhibitor, X5050 - Calbiochem

506026
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₅N₃O₃

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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable benzoimidazole derivative that acts as an inhibitor of repressor element-1 silencing transcription factor (REST, a Kruppel-type zinc finger transcription factor). Induces a dose-dependent reduction in the 122 kDa isoforms of REST in HEK cells. It is believed to target REST degradation, but not its expression or binding to repressor element binding sequence. Shown to rescue REST-regulated gene expressions, such as BDNF in the prefrontal cortex in mice with quinolinic acid-induced striatal lesions. Acute ventricular delivery of X5050 increases the expression of BDNFand other REST-regulated genes. Also shown to promote the expression of BDNF and SNAP25 in human neural stem cells via degradation of REST.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number506026
      Brand Family Calbiochem®
      SynonymsNeuron Resctrictive Silencer Factor (NRSF) Inhibitor, X5050, X-5050, Repressor Element-1 Silencing Transcription Factor (REST) Inhibitor, X5050
      References
      ReferencesCharbord, J., et al, 2013, Stem Cells 31, 1816.
      Product Information
      FormLight beige powder
      Hill FormulaC₁₇H₁₅N₃O₃
      Chemical formulaC₁₇H₁₅N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetREST
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      REST Inhibitor, X5050 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Charbord, J., et al, 2013, Stem Cells 31, 1816.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2016 JSW
      SynonymsNeuron Resctrictive Silencer Factor (NRSF) Inhibitor, X5050, X-5050, Repressor Element-1 Silencing Transcription Factor (REST) Inhibitor, X5050
      DescriptionA cell-permeable benzoimidazole derivative that acts as an inhibitor of repressor element-1 silencing transcription factor (REST, a Kruppel-type zinc finger transcription factor). Induces a dose-dependent reduction in the 122 kDa isoforms of REST in HEK cells. It is believed to target REST degradation, but not its expression or binding to repressor element binding sequence. Shown to rescue REST-regulated gene expressions, such as BDNF in the prefrontal cortex in mice with quinolinic acid-induced striatal lesions. Acute ventricular delivery of X5050 increases the expression of BDNFand other REST-regulated genes. Also shown to promote the expression of BDNF and SNAP25 in human neural stem cells via degradation of REST.
      FormLight beige powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₅N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCharbord, J., et al, 2013, Stem Cells 31, 1816.