557370 Rottlerin - CAS 82-08-6 - Calbiochem

557370
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₃₀H₂₈O₈82-08-6

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557370-10MGCN
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable and reversible protein kinase C inhibitor that exhibits greater selectivity for PKCδ (IC50 = 3-6 µM) and PKCθ. Inhibits the PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCζ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
      Catalogue Number557370
      Brand Family Calbiochem®
      SynonymsMallotoxin
      References
      ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
      Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
      Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
      Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
      Product Information
      CAS number82-08-6
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₃₀H₂₈O₈
      Chemical formulaC₃₀H₂₈O₈
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRottlerin, CAS 82-08-6, is a cell-permeable, reversible inhibitor of protein kinase C with greater selectivity for PKCδ (IC50 = 3-6 µM) & PKCθ. Has about 10-fold lower potency against other isozymes.
      Biological Information
      Primary TargetPKCδ
      Primary Target IC<sub>50</sub>3-6 µM against PKCδ; 5.3 µM against CaM kinase III
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAM6913800
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Rottlerin - CAS 82-08-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      557370

      References

      Reference overview
      Villalba, M., et al. 1999. J. Immunol. 163, 5813.
      Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
      Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
      Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.

      Citations

      Title
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
    • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
    • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsMallotoxin
      DescriptionA cell-permeable and reversible inhibitor of protein kinase C δ (PKCδ, IC50 = 3-6 µM) and PKCΘ isozymes. Also inhibits PKCα, PKCβ, and PKCγ isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCε, PKCη, and PKCξ (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM).
      FormOrange solid
      CAS number82-08-6
      RTECSAM6913800
      Chemical formulaC₃₀H₂₈O₈
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml) or Ethanol (1 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 8272
      ReferencesVillalba, M., et al. 1999. J. Immunol. 163, 5813.
      Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
      Gschwendt, M., et al. 1994. FEBS Lett. 338, 85.
      Gschwendt, M., et al. 1984. Cancer Lett. 25, 177.
      Citation
    • Phuong Thi Nguyen Sarkis, et al. (2006) STAT1-independent cell type-specific regulation of antiviral APOBEC3G by IFN-α. Journal of Immunology 177, 4530-4540.
    • Ying Zhang, Mingjuan Liao and Maria L. Dufau. (2006) Phosphatidylinositol 3-kinase/protein kinase Cγ-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene. Molecular and Cellular Biology 26, 6748-6761.
    • Yoon-Jin Lee, et al. (2005) HSP25 inhibits protein kinase Cγ-mediated cell death through direct interaction. Journal of Biological Chemistry 280, 18108-18119.