616454 TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem

616454
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₅H₁₉N₅S909910-43-6

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616454-2MGCN
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      Plastic ampoule 2 mg
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      Description
      OverviewA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
      Catalogue Number616454
      Brand Family Calbiochem®
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
      References
      ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.
      Product Information
      CAS number909910-43-6
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₅H₁₉N₅S
      Chemical formulaC₂₅H₁₉N₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary TargetALK-4/5/7
      Primary Target IC<sub>50</sub>45, 12, and 7.5 nM, respectively, in inhibit ALK-4/5/7-mediated luciferase transcription activity assays
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TGF-β RI Kinase Inhibitor IV - CAS 909910-43-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      616454

      References

      Reference overview
      Tojo, M., et al. 2005. Cancer Sci. 96, 791.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-January-2010 RFH
      SynonymsTransforming Growth Factor-β Type I Receptor Kinase Inhibitor IV, 3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole, A-83-01, ALK5 Inhibitor IV
      DescriptionA cell-permeable trisubstituted pyrazole compound that has been shown to selectively inhibit ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively, in luciferase transcription activity assays), but not ALK-1/2/3/6-mediated cellular signaling in Mv1Lu R4-2 transfectants expressing the individual Type I TGF-β receptors. Inhibits TGF-β-induced Smad2-phosphorylation in HaCaT cells and epithelial-to-mesenchymal transition in NMuMG cells at a concentration of 1 µM.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number909910-43-6
      Chemical formulaC₂₅H₁₉N₅S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesTojo, M., et al. 2005. Cancer Sci. 96, 791.