614853 Topoisomerase II Inhibitor, BNS-22 - Calbiochem

614853
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₄H₂₅NO₅

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614853-10MGCN
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      Glass bottle 10 mg
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      Description
      OverviewA potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
      Catalogue Number614853
      Brand Family Calbiochem®
      SynonymsBNS-22
      References
      ReferencesKawatani, M., et al. 2011. Chem Biol. 18, 743.
      Product Information
      FormWhite solid
      Hill FormulaC₂₄H₂₅NO₅
      Chemical formulaC₂₄H₂₅NO₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Topoisomerase II Inhibitor, BNS-22 - Calbiochem Certificates of Analysis

      TitleLot Number
      614853

      References

      Reference overview
      Kawatani, M., et al. 2011. Chem Biol. 18, 743.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-April-2012 JSW
      SynonymsBNS-22
      DescriptionA potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2α and TOP2β, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of γ-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₅NO₅
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (25 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKawatani, M., et al. 2011. Chem Biol. 18, 743.