506300 TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem

506300
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀O₄38183-03-8

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      Glass bottle 100 mg
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      Description
      OverviewA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
      Catalogue Number506300
      Brand Family Calbiochem®
      Synonyms7,8-DHF
      References
      ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
      Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
      Jang, S., et al. 2010. PNAS 107, 2687.
      Product Information
      CAS number38183-03-8
      FormYellow powder
      Hill FormulaC₁₅H₁₀O₄
      Chemical formulaC₁₅H₁₀O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTrkB
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TrkB Agonist, 7,8-Dihydroxyflavone - CAS 38183-03-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Ren, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
      Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
      Jang, S., et al. 2010. PNAS 107, 2687.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-November-2013 JSW
      Synonyms7,8-DHF
      DescriptionA cell permeable flavone based compound with neurotrophic and neuroprotective properties. Mimicks the action of Brain Derived Neurotrophic Factor (BDNF) and acts as a TrkB receptor agonist. Due to its lipophilic nature, it can cross the blood-brain barrier. Binds to the extra cellular domain of TrkB with high affinity and promotes its dimerization and autophosphorylation. Potentiates TrkB, but not TrkA, signaling in mouse brain slices. Its neurotropic effects are abolished in the presence of K252a. Suppresses apoptosis in human and rodent neurons and in stably transfected TrkB murine cell line T48 (EC50 = 35 nM). Selectively reduces the basal GABAergic transmission due to its suppressive effect on presynaptic GABA release. However, it does not affect glutamatergic transmission.
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number38183-03-8
      Chemical formulaC₁₅H₁₀O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesRen, Q., et al. 2013. Pharm. Biochem. Behav. 106, 124.
      Marongiu, D., et al. 2013. Eur. J. Pharmacol. 709, 64.
      Jang, S., et al. 2010. PNAS 107, 2687.