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662086 UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem

The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor

Primary Target: UCH-L1
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662086
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
668467-91-2C₁₇H₁₁Cl₃N₂O₃

Pricing & Availability

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662086-10MGCN
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      		 Glass bottle 10 mg
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      Description
      OverviewAn isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.
      Catalogue Number662086
      Brand Family Calbiochem®
      SynonymsLDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor
      References
      ReferencesLiu, Y., et al. 2003. Chem. Biol. 10, 837.
      Product Information
      CAS number668467-91-2
      ATP CompetitiveY
      FormOrange solid
      Hill FormulaC₁₇H₁₁Cl₃N₂O₃
      Chemical formulaC₁₇H₁₁Cl₃N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetUCH-L1
      Primary Target IC<sub>50</sub>0.88 µM
      Primary Target K<sub>i</sub>0.40 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      662086-10MGCN 04055977261134

      Documentation

      UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      662086

      References

      Reference overview
      Liu, Y., et al. 2003. Chem. Biol. 10, 837.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsLDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor
      DescriptionA potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM; IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µM. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson's disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number668467-91-2
      Chemical formulaC₁₇H₁₁Cl₃N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesLiu, Y., et al. 2003. Chem. Biol. 10, 837.