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506149 p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem

The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X

Primary Target: p53
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506149
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
213261-59-7C₁₄H₁₂O₃S₂

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      Description
      OverviewA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
      Catalogue Number506149
      Brand Family Calbiochem®
      SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
      References
      ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
      Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
      Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
      Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
      Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.
      Product Information
      CAS number213261-59-7
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₄H₁₂O₃S₂
      Chemical formulaC₁₄H₁₂O₃S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp53
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      506149-1MGCN 07790788050870

      Documentation

      p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      p53 Activator III, RITA - CAS 213261-59-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      506149

      References

      Reference overview
      Grinkevich, V., et al. 2005. Nat. Med. 11, 1136.
      Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
      Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
      Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
      Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.

      Brochure

      Title
      Interactive Pathway Calendar
      p53 And Related Products
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-August-2008 RFH
      SynonymsNSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
      DescriptionA cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number213261-59-7
      Chemical formulaC₁₄H₁₂O₃S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (3 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesGrinkevich, V., et al. 2005. Nat. Med. 11, 1136.
      Krajewski, M., et al. 2005. Nat. Med. 11, 1135.
      Issaeva, N., et al. 2004. Nat. Med. 10, 1321.
      Nieves-Neira, W., et al. 1999. Mol. Pharmacol. 56, 478.
      Rivera, M.I., et al. 1999. Biochem. Pharmacol. 57, 1283.