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554720 trans-Retinoic Acid - CAS 302-79-4 - Calbiochem

Potent modulator of growth and differentiation. Inhibits melanocyte adhesion, motility, and growth.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Tretinoin, ATRA, Vitamin A Acid

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554720
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
302-79-4C₂₀H₂₈O₂

Pricing & Availability

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554720-500MGCN
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      		 Glass bottle 500 mg
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      Description
      OverviewPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells. PROTECT FROM AIR.
      Catalogue Number554720
      Brand Family Calbiochem®
      SynonymsTretinoin, ATRA, Vitamin A Acid
      References
      ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
      Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
      Labbaye, C., et al. 1993. Blood 81, 475.
      Sakashita, A., et al. 1993. Blood 81, 1009.
      Situ, R., et al. 1993. Dermatology 186, 38.
      Tini, M., et al. 1993. Genes Develop. 7, 295.
      Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
      Sharpe, C.R. 1991. Neuron 7, 239.
      Thaller, C. and Eichele, G. 1990. Nature 345, 815.
      Product Information
      CAS number302-79-4
      FormYellow solid
      Hill FormulaC₂₀H₂₈O₂
      Chemical formulaC₂₀H₂₈O₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by assay
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSVH6475000
      Safety Information
      R PhraseR: 22-36/37/38-63

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      554720-500MGCN 04061838431332

      Documentation

      trans-Retinoic Acid - CAS 302-79-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      trans-Retinoic Acid - CAS 302-79-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      554720

      References

      Reference overview
      Tosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
      Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
      Labbaye, C., et al. 1993. Blood 81, 475.
      Sakashita, A., et al. 1993. Blood 81, 1009.
      Situ, R., et al. 1993. Dermatology 186, 38.
      Tini, M., et al. 1993. Genes Develop. 7, 295.
      Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
      Sharpe, C.R. 1991. Neuron 7, 239.
      Thaller, C. and Eichele, G. 1990. Nature 345, 815.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-October-2007 RFH
      SynonymsTretinoin, ATRA, Vitamin A Acid
      DescriptionPotent modulator of growth and differentiation. Exerts its effects by binding to nuclear retinoic acid receptors (RARs) which directly regulate gene expression. Inhibits melanocyte adhesion, motility, and growth. Has keratolytic activity. Induces differentiation of tumor cells of neural origin. Induces apoptosis in acute promyelocytic carcinoma cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number302-79-4
      RTECSVH6475000
      Chemical formulaC₂₀H₂₈O₂
      Structure formulaStructure formula
      Purity≥95% by assay
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). DMSO stock solutions are stable for up to 2 weeks at 4°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 8165
      ReferencesTosi, P., et al. 1994. Leuk. Lymphoma 14, 503.
      Clagett-Dame, M., et al. 1993. Arch. Biochem. Biophys. 300, 684.
      Labbaye, C., et al. 1993. Blood 81, 475.
      Sakashita, A., et al. 1993. Blood 81, 1009.
      Situ, R., et al. 1993. Dermatology 186, 38.
      Tini, M., et al. 1993. Genes Develop. 7, 295.
      Leid, M., et al. 1992. Trends Biochem. Sci. 17, 427.
      Sharpe, C.R. 1991. Neuron 7, 239.
      Thaller, C. and Eichele, G. 1990. Nature 345, 815.