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Transcription Factors and RNA Binding Proteins

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Transcription Factors

Transcription factors are frequently the chief determinants of the composition and stability of large transcription complexes. Transcription factors bind to promoters and enhancers on DNA and help to recruit RNA polymerases to active genes for the production of RNA transcripts. Merck offers a range of monoclonal and polyclonal transcription factor antibodies as well as antibodies against various RNA polymerases, their subunits, and post transcriptional regulation elements.

Backed by peer reviewed publications with proven performance in applications such as Western blotting, immunoprecipitation, immunocytochemistry, and immunohistochemistry, Merck transcription and post-transcriptional regulation antibodies have helped researchers worldwide advance their research. Click on the link below to browse our selection of antibodies or use our antibody search tool to find the exact antibody you need.

Transcription Factor Antibodies

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Transcription Factor Assays

Featured Antibody: Anti-NRF-1
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Untreated (left) or 25 µM DCM-treated (right) H9c2 cardiomyoblasts were stained using Anti-NRF-1 (Cat. No. ABE1844, red) Hoechst dye nuclear counterstain is shown in blue. Data courtesy of Hagir B. Suliman and Claude A. Piantadosi, Duke University Medical Center. Dichloromethane (DCM) induces NRF-1 nuclear localization.

RNA-Binding Proteins and Modified RNA

RNA-binding proteins (RBPs) interact with double or single stranded RNA. These proteins can be found in the cytoplasm or the nucleous of a cell and interact with a variety of RNAs (mRNA, rRNA, lncRNA snRNA etc.) to form ribonucleoproteins (RNPs) and heteronuclear proteins. (hnRNPs). These RNA-protein complexes play roles in mRNA splicing, polyadenylation, as well as RNA stabilization, localization and translation.

In addition to interacting with a variety of RNA binding proteins, RNA molecules can contain a number of post-transcriptional modifications. Modification such as N6-methyladenosine (m6A) and 5-methylcytidine (5-mC) have been described.

Merck offers a variety of antibodies ideal for the study of RNA binding proteins and modified RNA. Click on the link below to browse our collection of RNA binding protein antibodies proven in applications such as RNA binding protein immunoprecipitation (RIP) and modified RNA antibodies with proven performance in peer-review journals and dot blot validated specificity.
Related Products:
RIP Kits 

Featured Antibody: Anti-Pumilio-2 (PUM2)
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Staining of mouse and human embryonic stem cells using Anti-Pumilio 2 (PUM2) (Cat. No. AB10181, red). Actin filaments have been labeled with AlexaFluor®488-Phalloidin (green). Nuclei are stained with DAPI (blue). This antibody positively stains the nucleus and cytosol.