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Merck

194557

Methoxyacetic acid

98%

Synonym(s):

NSC 7300

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About This Item

Linear Formula:
CH3OCH2COOH
CAS Number:
625-45-6
Molecular Weight:
90.08
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24851659
EC Number:
210-894-6
Beilstein/REAXYS Number:
635800
MDL number:
MFCD00004308
Assay:
98%
Form:
liquid

Key Documents

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InChI key

RMIODHQZRUFFFF-UHFFFAOYSA-N

InChI

1S/C3H6O3/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)

SMILES string

COCC(O)=O

assay

98%

form

liquid

Quality Level

200

bp

202-204 °C (lit.)

mp

7-9 °C (lit.)

density

1.174 g/mL at 25 °C (lit.)

functional group

carboxylic acid, ether

Related Categories

General description

Methoxyacetic acid is the major metabolite of ester phthalates widely used in industry as gelling, viscosity and stabilizer reagents.

Application

Methoxyacetic acid was used in zebrafish embryotoxicity test to evaluate chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1B - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

237.2 °F - closed cup

flash_point_c

114 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB1103
STBK6197
STBK9576
STBK1290
STBJ6002

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Bo Yang et al.
Urology, 81(3), 696-696 (2013-01-08)
To investigate the expression pattern of Ras-related protein 1 (Rap1) during testicular development and to clarify whether its expression is developmentally regulated and whether this expression is involved in the process of germ cell apoptosis. The expression pattern of Rap1
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 9, 42-42 (2011-04-02)
Optimal androgen signaling is critical for testicular development and spermatogenesis. Methoxyacetic acid (MAA), the primary active metabolite of the industrial chemical ethylene glycol monomethyl ether, disrupts spermatogenesis and causes testicular atrophy. Transcriptional trans-activation studies have indicated that MAA can enhance
Derek V Henley et al.
Environmental health perspectives, 117(11), 1702-1706 (2010-01-06)
Ethylene glycol monomethyl ether (EGME) exposure is associated with impaired reproductive function. The primary metabolite of EGME is methoxyacetic acid (MAA), a short-chain fatty acid that inhibits histone deacetylase activity and alters gene expression. Because estrogen signaling is necessary for
Gargi Bagchi et al.
Reproductive biology and endocrinology : RB&E, 8, 65-65 (2010-06-23)
Methoxyacetic acid (MAA) is the active metabolite of the widely used industrial chemical ethylene glycol monomethyl ether, which is associated with various developmental and reproductive toxicities, including neural toxicity, blood and immune disorders, limb degeneration and testicular toxicity. Testicular toxicity
Didik Priyandoko et al.
PloS one, 6(5), e19552-e19552 (2011-05-17)
The present day lifestyle heavily depends on industrial chemicals in the form of agriculture, cosmetics, textiles and medical products. Since the toxicity of the industrial chemicals has been a concern to human health, the need for alternative non-toxic natural products
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