207713
1,3-Di-o-tolylguanidine
99%
Synonym(s):
DTG
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About This Item
Linear Formula:
(CH3C6H4NH)2C(=NH)
CAS Number:
Molecular Weight:
239.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
202-577-6
MDL number:
Assay:
99%
Form:
solid
InChI key
OPNUROKCUBTKLF-UHFFFAOYSA-N
InChI
1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
SMILES string
Cc1ccccc1NC(=N)Nc2ccccc2C
assay
99%
form
solid
mp
176-178 °C (lit.)
solubility
water: soluble 70 mg/mL at 20 °C
functional group
amine
Quality Level
Gene Information
human ... EBP(10682)
Related Categories
General description
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
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Thibault Mesplède et al.
AIDS (London, England), 29(6), 659-665 (2015-04-08)
In treatment-naive HIV-positive individuals, the integrase strand-transfer inhibitor dolutegravir (DTG) has not been associated with emergent drug-resistance mutations, neither against this drug nor against other antiretroviral drugs that were used in combination with it. This is in contrast to all
F P Monnet et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 705-712 (2003-09-17)
Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 receptor agonists potentiate NMDA receptor-mediated neuronal activity in the hippocampus and recruit Ca2+-dependent second
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A facile electrochemical sandwich immunosensor for the detection of a breast cancer biomarker, the human epidermal growth factor receptor 2 (HER2), was designed, using lead sulfide quantum dots-conjugated secondary HER2 antibody (Ab2-PbS QDs) as a label. Using Ab2-PbS QDs in
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Scientific reports, 10(1), 21521-21521 (2020-12-11)
The use of nanocarriers composed of polyethylene glycol- and polyvinyl alcohol-coated vesicles encapsulating active molecules in place of conventional chemotherapy drugs can reduce many of the chemotherapy-associated challenges because of the increased drug concentration at the diseased area in the
Moya A Hay et al.
Chemical science, 10(25), 6354-6361 (2019-07-26)
The magnetic properties of 3d monometallic complexes can be tuned through geometric control, owing to their synthetic accessibility and relative structural simplicity. Monodentate ligands offer great potential for fine-tuning the coordination environment to engineer both the axial and rhombic zero-field
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