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Merck

674648

(S)-(−)-2-Methyl-CBS-oxazaborolidine solution

1 M in THF

Synonym(s):

α,α-Diphenyl-L-prolinol methylboronic acid cycl-amide ester, (S)-1-Methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2c][1,3,2]oxazaborole, (S)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole, (S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole

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About This Item

Empirical Formula (Hill Notation):
C18H20BNO
CAS Number:
112022-81-8
Molecular Weight:
277.17
NACRES:
NA.22
PubChem Substance ID:
24885227
UNSPSC Code:
12352005
MDL number:
MFCD00078439

Product Name

(S)-(−)-2-Methyl-CBS-oxazaborolidine solution, 1 M in THF

InChI

1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m0/s1

SMILES string

CB1OC([C@@H]2CCCN12)(c3ccccc3)c4ccccc4

InChI key

VMKAFJQFKBASMU-KRWDZBQOSA-N

concentration

1 M in THF

refractive index

n20/D 1.460

density

0.942 g/mL at 25 °C

functional group

phenyl

Quality Level

100

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Application

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis
The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols, and propargyl alcohols.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH018,EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

5.0 °F - closed cup

flash_point_c

-15 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBQ3479
37296LM
30197PJ
05026EE

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Corey, E. J. et al.
Journal of the American Chemical Society, 109, 5551-5551 (1987)
Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones.
Kathlyn A. Parker et al.
The Journal of organic chemistry, 61(9), 3214-3217 (1996-05-03)
Schwink, L.; Knochel, P.
Tetrahedron Letters, 37, 25-25 (1996)
Corey, E. J.; Link, J. O.
Tetrahedron Letters, 33, 3431-3431 (1992)
Togni, A.; Venanzi, L. M.
Angewandte Chemie (International Edition in English), 33, 497-497 (1994)
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