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Merck

W253901

γ-Heptalactone

≥98%, FCC, FG

Synonym(s):

(±)-4-Heptanolide, (±)-γ-Propyl-γ-butyrolactone, (±)-Dihydro-5-propyl-2(3H)-furanone

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About This Item

Empirical Formula (Hill Notation):
C7H12O2
CAS Number:
105-21-5
Molecular Weight:
128.17
FEMA Number:
2539
Council of Europe no.:
2253
UNSPSC Code:
12164502
PubChem Substance ID:
24901126
Flavis number:
10.020
EC Number:
203-279-9
NACRES:
NA.21
MDL number:
MFCD00036498
Beilstein/REAXYS Number:
109569
Organoleptic:
coconut; creamy; sweet
Grade:
FG, Fragrance grade, Halal, Kosher
Biological source:
synthetic
Agency:
follows IFRA guidelines, meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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SMILES string

CCCC1CCC(=O)O1

InChI key

VLSVVMPLPMNWBH-UHFFFAOYSA-N

InChI

1S/C7H12O2/c1-2-3-6-4-5-7(8)9-6/h6H,2-5H2,1H3

biological source

synthetic

grade

FG, Fragrance grade, Halal, Kosher

agency

follows IFRA guidelines, meets purity specifications of JECFA

reg. compliance

EU Regulation 1223/2009, EU Regulation 1334/2008 & 178/2002, FCC, FDA 21 CFR 117, FDA 21 CFR 172.515

assay

≥98%

Quality Level

300, 400

Gene Information

human ... CYP1A2(1544)

bp

61-62 °C/2 mmHg (lit.)

density

0.999 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

organoleptic

coconut; creamy; sweet

Related Categories

General description

γ-Heptalactone is a volatile flavor compound found in mangoes, strawberries, pineapples as well as in some dairy products. It is used as a flavoring agent in the food and cosmetic industry.

Application


  • Enzymes with Lactonase Activity against Fungal Quorum Molecules as Effective Antifungals.: This study investigates the potential of lactonase enzymes in combating fungal infections by disrupting fungal communication systems. The findings indicate significant antifungal activity, suggesting applications in developing new antifungal treatments (Efremenko et al., 2024).

  • Product study of the reactions of gamma-caprolactone and gamma-heptalactone initiated by OH radicals at 298 K and atmospheric pressure: Formation of acyl peroxynitrates (APN).: This research explores the chemical reactions of gamma-heptalactone with OH radicals, leading to the formation of acyl peroxynitrates, which are significant in atmospheric chemistry and pollution studies (Baptista et al., 2023).

  • Effect of gamma-Heptalactone on the Morphology and Production of Monascus Pigments and Monacolin K in Monascus purpureus.: The paper examines how gamma-heptalactone influences the production of bioactive compounds in Monascus purpureus, with implications for food and pharmaceutical industries (Shi et al., 2022).

  • RIFM fragrance ingredient safety assessment, gamma-heptalactone, CAS Registry Number 105-21-5.: This safety assessment evaluates gamma-heptalactone as a fragrance ingredient, ensuring its safe use in various consumer products (Api et al., 2019).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315

Hazard Classifications

Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS7222
SHBR9827
SHBR0027
SHBM4218
SHBM0688

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Insights into protein recognition for γ-lactone essences and the effect of side chains on interaction via microscopic, spectroscopic, and simulative technologies
Sun Q, et al.
Food Chemistry, 278, 127-135 (2019)
Mango flavor
Chauhan OP, et al.
Handbook of Acid-Base Indicators, 319-319 (2010)
Identification, quantitation and sensorial contribution of lactones in brandies between China and France
LiYuanyi, et al.
Food Chemistry, 129761-129761 (2021)
Laura E Korhonen et al.
Journal of medicinal chemistry, 48(11), 3808-3815 (2005-05-27)
The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-activity relationship (3D-QSAR) model of CYP1A2 inhibitors and to use this model to predict the

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