Anti-SETDB2 Antibody, clone 5B7.2

SET domain bifurcated 2 (SETDB2), also known as Histone-lysine N-methyltransferase SETDB2 is a ubiquitous, nuclear protein belonging to the histone-lysine methyltransferase family and is comprised of a MBD (Methyl-CpG-binding) domain, a pre-SET domain, and a SET domain. Data suggests that SETDB2 is a methyltransferase with specific activity against histones. Studies also suggest that it may be a key regulatory component in the development of dorsal organizer and left-right asymmetry during early embryonic development by downregulating fibroblast growth factor 8. Although expression of the protein is considered ubiquitous, high levels have been reported in heart, ovary and testis tissues.

~ 80 kDa observed

Recombinant protein corresponding to human SETDB2.

Research Category
Epigenetics & Nuclear Function

Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

Histone Modifying Proteins

Use Anti-SETDB2 Antibody, clone 5B7.2 (mouse monoclonal antibody) validated in WB to detect SETDB2 also known as SET domain bifurcated 2, chronic lymphocytic leukemia deletion region 8, histone-lysine N-methyltransferase SETDB2.

Format: Purified

Ion Exchange

Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
A431 cell lysate

Evaluated by Western Blot in A431 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected SETDB2 on 10 µg of A431 cell lysate.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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