Anti-Fos Antibody

55kDa

The v-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.

c-Fos and v-Fos

Trp E fusion-protein corresponding to the N-terminal fragment containing amino acid residues 75-155 of human v-Fos

Detect Fos with Anti-Fos Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Replaces: CBL441

Immunoaffinity Chromatography

PBS containing 2mg/ml BSA and 0.2% sodium azide

1 year at -20°C

Control
Serum-stimulated Hela cell lysate, phorbol ester-treated and EGF-treated A-431 nuclear cell extracts

routinely evaluated by immunoblot on RIPA lysate of human HeLa nuclear extract

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