Key Documents
09-267
Anti-human Tks4 Antibody
from rabbit
Synonym(s):
Adapter protein HOFI, Factor for adipocyte differentiation 49, SH3 and PX domains 2B, adaptor protein HOFI
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
General description
Tks4 (gene symbol SH3PXD2B) is a novel adaptor protein; also known as SH3 and PX domain-containing protein 2B, (Courtneidge, 2005). It is closely related to Tks5 (gene symbol SH3PXD2A) and like Tks5, appears to play a role in the formation and function of podosome/invadopodia based on studies of Src-transformed fibroblasts (Buschman, 2009). Additionally, Tks4 may be involved in the recruitment of MT1-MMP and ECM degradation.
Tks4 is broadly expressed and localizes in the cytoplasm of the podosome.
Tks4 is broadly expressed and localizes in the cytoplasm of the podosome.
~ 130 kDa
Immunogen
Epitope: a. a. 431-595
Recombinant protein containing amino acids 431-595 of human Tks4.
Application
Research Category
Signaling
Cell Structure
Signaling
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeletal Signaling
Cytoskeleton
Cytoskeletal Signaling
This Anti-human Tks4 Antibody is validated for use in WB, IP for the detection of human Tks4.
Biochem/physiol Actions
Human and mouse (76% homology). Reactivity with other species has not been tested.
Predicted to cross react with rat (77% homology).
The antibody recognizes human Tks4.
Physical form
Format: Purified
Protein A purified
Purified in 0.1M Tris-Glycine, pH 7.4, 150 mM NaCl with 0.05% NaN3.
Preparation Note
Maintain at 2-8°C for up to 1 year from date of receipt.
Analysis Note
Control
NIH3T3 cell lysate.
NIH3T3 cell lysate.
Evaluated on a representative lot by Immunoprecipitation followed by Western blot on NIH3T3 cell lysate using Anti-human Tks4.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Shinji Iizuka et al.
Oncotarget, 7(48), 78473-78486 (2016-11-02)
Metastatic cancer cells are characterized by their ability to degrade and invade through extracellular matrix. We previously showed that the Tks adaptor proteins, Tks4 and Tks5, are required for invadopodia formation and/or function in Src-transformed fibroblasts and a number of
Livia Caires-Dos-Santos et al.
Journal of cellular physiology, 235(1), 587-598 (2019-06-30)
Laminin peptides influence cancer biology. We investigated the role of a laminin-derived peptide C16 regulating invadopodia molecules in human prostate cancer cells (DU145). C16 augmented invadopodia activity of DU145 cells, and stimulated expression Tks4, Tks5, cortactin, and membrane-type matrix metalloproteinase
The SRC substrate Tks5, podosomes (invadopodia), and cancer cell invasion.
Courtneidge, S A, et al.
Cold Spring Harbor Symposia on Quantitative Biology, 70, 167-171 (2005)
Bálint Szeder et al.
Cells, 8(11) (2019-11-02)
Epithelial to mesenchymal transition (EMT) is a multipurpose process involved in wound healing, development, and certain pathological processes, such as metastasis formation. The Tks4 scaffold protein has been implicated in cancer progression; however, its role in oncogenesis is not well
Matthew D Buschman et al.
Molecular biology of the cell, 20(5), 1302-1311 (2009-01-16)
Metastatic cancer cells have the ability to both degrade and migrate through the extracellular matrix (ECM). Invasiveness can be correlated with the presence of dynamic actin-rich membrane structures called podosomes or invadopodia. We showed previously that the adaptor protein tyrosine
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