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104648

Cellvento® ModiFeed Gal- COMP

Chemically defined cell culture feed - EMPROVE® CCM

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Synonym(s):

Animal-Free Fed-Batch CHO Feed, CHO Glycosylation Control Feed, Cellvento® ModiFeed Gal, Galactosylation-Reducing CHO Feed, Glycan Modulation Feed, Low Galactosylation CHO Feed

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About This Item

UNSPSC Code:
41106213
Technical Service
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Product Name

Cellvento® ModiFeed Gal- COMP, Chemically defined, CHO fed-batch feed for galactosylation reduction, EMPROVE® CCM

Quality Segment

500

biological source

non-animal source

description

shipped with cooling packs

product line

Cellvento®

form

compacted dry powder

greener alternative product characteristics

Design for Energy Efficiency
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

technique(s)

cell culture | mammalian: suitable

application(s)

pharma/biopharma processes

components

glucose: no

greener alternative category

DfS-Developed

storage temp.

2-8°C

General description

Cellvento®ModiFeed Gal- COMP is a chemically defined, animal-component-free cell culture feed developed for CHO fed-batch bioprocessing and targeted control of terminal galactosylation. As part of the Cellvento® ModiFeed platform, this highly concentrated, compacted dry powder is a complete, single-part, pH-neutral feed that replenishes essential nutrients while supporting increased G0(F) and reduced G1(F)/G2(F) glycan levels. The formulation contains no glucose, hydrolysates, phenol red, or 2-mercaptoethanol (2-ME), helping simplify feed preparation and process integration. On combination with Cellvento®ModiFeed Prime it allows tunable galactosylation.

Cellvento® ModiFeed Gal- COMP is supported by the Emprove® Program and designated DfS, making it suitable for scalable, quality-focused biologics manufacturing workflows.

We are committed to bringing you Greener Alternative Products, which belongs to one of the four categories of greener alternatives. This product is a Design for Sustainability (DfS) developed product. Click here to view its DfS scorecard.

Application

Cellvento® ModiFeed Gal- COMP Suitable for
  • CHO-based mAb & biosimilar development and commercial manufacturing
  • Fed-batch bioprocessing requiring reduced terminal galactosylation (↑G0F, ↓G1F/G2F)
  • Process intensification via high-concentration, reduced-volume feedingGlycosylation tuning in combination with Cellvento® ModiFeed Prime COMP
  • CHO suspension cell lines including CHO-S, CHO-DHFR⁻, CHO-K1, CHO-GS, and CHOZN®
  • Compatible with Cellvento® 4CHO COMP and EX-CELL® Advanced CHO production media for a fully integrated, chemically defined upstream process platform

Features and Benefits

  • One-part, pH-neutral complete feed for simplified fed-batch process
  • Maximizes terminal galactosylation without compromising titer
  • Highly concentrated to reduce feed volume added to bioreactor
  • Compacted powder for convenient handling and easy hydration
  • Ambient-stable hydrated solution up to 30 days
  • Chemically defined, no animal-origin components
  • No glucose enabling precise glucose control
  • Supported by EMPROVE® CCM Program

Preparation Note

Formulated to contain 143.6 grams of powder per liter of feed.

Legal Information

CELLVENTO is a registered trademark of Merck KGaA, Darmstadt, Germany
EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 3

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