Key Documents
120002
Adenylyl-imidodiphosphate, Tetralithium Salt - CAS 72957-42-7 - Calbiochem
Synonym(s):
Adenosine 5ʹ-(β,γ-imido)triphosphate, AMP-PNP, 4Li
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General description
A non-hydrolyzable ATP analog that acts as a competitive inhibitor of ATP-dependent enzyme systems. Known to block ATP-sensitive Ca2+-activated K+ channels.
A non-hydrolyzable ATP analog that acts as a competitive inhibitor of ATP-dependent enzyme systems. Known to block ATP-sensitive K+ channels.
Application
Adenylyl-imidodiphosphate, Tetralithium Salt, CAS 72957-42-7, is a non-hydrolyzable ATP analog. A competitive inhibitor of ATP-dependent enzymes. Block ATP-sensitive Ca2+-activated K+ channels.
Biochem/physiol Actions
ATP-sensitive Ca2+-activated K+ channels.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 2 days at 4°C or for up to 3 months at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
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Z W Wang et al.
The American journal of physiology, 271(1 Pt 1), L100-L105 (1996-07-01)
The regulation of calcium-activated potassium (KCa) channels by endogenous protein kinase A (PKA) was examined in inside-out patches from equine tracheal myocytes. In the absence of exogenous protein kinases, ATP (500 microM) significantly augmented KCa channel activity when applied to
Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P--N--P linkage.
R G Yount et al.
Biochemistry, 10(13), 2484-2489 (1971-06-22)
S Hehl et al.
European biophysics journal : EBJ, 23(4), 231-237 (1994-01-01)
Single ATP-sensitive potassium channels (KATP channels) were studied in inside-out membrane patches excised from mouse skeletal muscle. Channel blockage by the non-hydrolysable ATP analogue AMP-PNP was investigated in the absence or presence of 1 mM MgCl2 with K(+)-rich solutions bathing
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