178260
Anti-α₁-Antitrypsin Mouse mAb (TMF1#4B5)
liquid, clone TMF1#4B5, Calbiochem®
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About This Item
UNSPSC Code:
12352203
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
TMF1#4B5, monoclonal
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
isotype
IgG2a
shipped in
wet ice
storage temp.
−20°C
General description
Purified mouse monoclonal antibody. Recognizes α1-antitrypsin in human serum.
Recognizes α1-antitrypsin in human serum. Does not cross-react with α1-acid glycoprotein, serum albumin, or other serum proteins.Antibody Target Gene Symbol: SerpinA3 Target Synonym: AACT, ACT, ALPHA 1 ANTICHYMOTRYPSIN, ALPHA1 ACT, Alpha1-antitrypsin proteinase inhibitor, Anti-chymotrypsin, Contrapsin Like Protease Inhibitor Related, Contraspin-like protease inhibitor, CPi-26, Eb22/5, GIG24, GIG25, MGC88254, MGC93363, Serine protease inhibitor, Serpina3n, Spi-2.2, SPI2-2, Spi2/eb.4, SPI3, Spin2c, Spin3 Entrez Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Hu Entrez ID: 12 Mu Entrez ID: 20716 Rat Entrez ID: 24795
This Anti-α₁-Antitrypsin Mouse mAb (TMF1#4B5) is validated for use in Enzyme Immunoassay, Radioimmunoassay for the detection of α₁-Antitrypsin.
Immunogen
Human
purified human α₁-antitrypsin
Application
Enzyme Immunoassay (see comments)
Radioimmunoassay (see comments)
Radioimmunoassay (see comments)
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, pH 7.4.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Does not cross-react with α1-acid glycoprotein, serum albumin, or other serum proteins. Affinity constant: 1 x 109 l/mol. For EIA and RIA, antibody should be titrated for each individual system.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Highly Toxic (H)
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Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A Lieber et al.
Journal of virology, 72(11), 9267-9277 (1998-10-10)
NF-kappaB is a key regulator of the innate antiviral immune response, due in part to its transcriptional activation of cytokines and adhesion molecules, which, in turn, function in chemotaxis and activation of inflammatory cells. We reported earlier that viral gene
A Lieber et al.
Journal of virology, 71(11), 8798-8807 (1997-10-29)
Systemic application of first-generation adenovirus induces pathogenic effects in the liver. To begin unraveling the mechanisms underlying early liver toxicity after adenovirus infusion, particularly the role of macrophage activation and expression of viral genes in transduced target cells, first-generation adenovirus
Floran Begue et al.
Scientific reports, 11(1), 2291-2291 (2021-01-29)
Coronavirus disease 2019 (COVID-19) pandemic is affecting millions of patients worldwide. The consequences of initial exposure to SARS-CoV-2 go beyond pulmonary damage, with a particular impact on lipid metabolism. Decreased levels in HDL-C were reported in COVID-19 patients. Since HDL
Guadalupe Ortiz-Muñoz et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(9), 3129-3139 (2009-05-07)
Various studies using proteomic approaches have shown that HDL can carry many proteins other than its constitutive apolipoprotein A-I (apoA-I). Using mass spectrometry and Western blotting, we showed the presence of alpha(1)-antitrypsin (AAT) (SERPINA1, serpin peptidase inhibitor, clade A, an
Robustness of iCIEF methodology for the analysis of monoclonal antibodies: an interlaboratory study.
Oscar Salas-Solano et al.
Journal of separation science, 35(22), 3124-3129 (2012-10-16)
An international team including 12 laboratories from 11 independent biopharmaceutical companies in the United States and Switzerland was formed to evaluate the precision and robustness of imaged capillary isoelectric focusing for the charge heterogeneity analysis of monoclonal antibodies. The different
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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