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197223

Sigma-Aldrich

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem

Synonym(s):

Bcr-abl Inhibitor II - CAS 607702-99-8 - Calbiochem, 5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II

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About This Item

Empirical Formula (Hill Notation):
C16H11F2N3OS2
CAS Number:
607702-99-8
Molecular Weight:
363.40
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

This product has been discontinued.



A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.

A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.

Other Notes

Radi, M., et al. 2008. Bioorg. Med. Chem. Lett.18, 1207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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