200498
Betulinic Acid - CAS 472-15-1 - Calbiochem
Synonym(s):
3β-Hydroxy-20(29)-lupaene-28-oic Acid
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About This Item
Assay
>97% (HPLC)
form
solid
color
colorless
solubility
DMSO: 1 mg/mL
General description
Antitumor and anti-HIV agent. A pentacyclic triterpene that selectively inhibits human melanoma in cell culture and in animal models. Appears to act specifically on melanoma cells without affecting other types of tumors. The antitumor effects of betulinic acid appear to be associated with the induction of mitochondrial permeability transition pore that triggers apoptosis. Also acts as a potent inhibitor of Hh/Gli signaling pathway inhibitor (IC50 = 32 μM).
Biochem/physiol Actions
Inhibits human melanoma in cell culture and in animal models
Target IC50:32 μM inhibiting Hh/Gli signaling pathway
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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