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Key Documents

201125

Sigma-Aldrich

Binucleine 2 - CAS 220088-42-6 - Calbiochem

Synonym(s):

Binucleine 2 - CAS 220088-42-6 - Calbiochem, Nʹ-(1-(3-Chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl)-N,N-dimethyliminoformamide, Aurora Kinase Inhibitor VII

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About This Item

Empirical Formula (Hill Notation):
C13H11ClFN5
CAS Number:
220088-42-6
Molecular Weight:
291.71
MDL number:
MFCD00177827
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

brown

solubility

DMSO: 10 mg/mL
methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable pyrazolo compound that inhibits cytokinesis function of the Aurora B kinase pathway. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, while inactive in mammalian systems. Does neither function as a general kinase inhibitor nor inhibit Cdk-dependent entry into mitosis.
A cell-permeable pyrazolo compound that inhibits the cytokinesis function of the Aurora B kinase pathway. Shown to inhibit Aurora β-dependent phosphorylation, but not a general kinase inhibitor. Inhibits Histone H3 phosphorylation on Ser10 in mitotic Drosophila Kc167 cells at 20 µM, but is inactive in mammalian systems. Inhibit Cdk-dependent entry into mitosis.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eggert, U.S., et al. 2004. PLoS Biol.2, 2135.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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