Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem

Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨ_m), as well as a number of other phenomena linked to apoptosis.

Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.

Cell permeable: no

Primary Target
Mitochondrial mega channel

Product does not compete with ATP.

Reversible: no

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

Hirsch, T., et al. 1998. J. Immunol. 161, 35.
Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Harmful & Carcinogenic / Teratogenic (E)