218841
InSolution Caspase-9 Inhibitor I - Calbiochem
The InSolution Caspase-9 Inhibitor I controls the biological activity of Caspase-9. This small molecule/inhibitor is primarily used for Cancer applications.
Synonym(s):
InSolution Caspase-9 Inhibitor I - Calbiochem, Z-LE(OMe)HD(OMe)-FMK
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About This Item
Empirical Formula (Hill Notation):
C32H43FN6O10
Molecular Weight:
690.72
UNSPSC Code:
12352200
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
shipped in
wet ice
storage temp.
−20°C
General description
A 5 mM (250 µg/72 µl) solution of Z-LEHD-FMK (Cat. No. 218761) in DMSO. A potent, cell-permeable, and irreversible inhibitor of caspase-9 (ICE-LAP6, Mch6).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
caspase-4, caspase-5, caspase-9
caspase-4, caspase-5, caspase-9
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Physical form
A 5 mM solution of Z-LEHD-FMK (Cat. No. 218761) in DMSO.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Analysis Note
single spot by TLC
Other Notes
Fadeel, B., et al. 1999. Leukemia13, 719.
Z-Leu-Glu(OMe)-His-Asp(OMe)-CH₂F*
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
188.6 °F - (refers to pure substance)
Flash Point(C)
87 °C - (refers to pure substance)
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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