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219505

Sigma-Aldrich

CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem

Synonym(s):

CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem, 5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I

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About This Item

Empirical Formula (Hill Notation):
C12H14N2OS
CAS Number:
493028-20-9
Molecular Weight:
234.32
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

tan

solubility

DMSO: 20 mg/mL
ethanol: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~ 100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor′s antiproliferative activity and the Runx1 expression level in the target cells.

A cell-permeable thiazolyl compound that binds to CBFβ (core binding factor β) and allosterically disrupts CBFα/Runx1 binding to CBFβ both in cell-free binding studies (IC50 of ~3.5 µM by FRET and ELISA) and in HEK293 cells (IC50 of ~100 µM by FACS/FRET). Cellular studies indicate a good correlation between the inhibitor′s antiproliferative activity and the Runx1 expression level in the target cells.

Other Notes

Gorczynski, M.J., et al. 2007. Chem. Biol.14, 1186.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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